For Physicians

EXOGEN® has demonstrated proven clinical effectiveness2-4 and 91% treatment compliance.21 Using low-intensity pulsed ultrasound (LIPUS) technology, EXOGEN activates a biological healing response at the molecular level.11 Now featuring a built-in treatment tracking calendar, EXOGEN makes treatment compliance tracking convenient for your patients and verifiable for you.

EXOGEN mechanism of action

  1. 1. Stimulation EXOGEN sends ultrasound waves through the skin and soft tissue to the fracture.
  2. 2. Activation EXOGEN ultrasound activates cell surface mechanoreceptors called integrins, initiating an intracellular cascade that leads to upregulation.
  3. 3. Upregulation EXOGEN ultrasound increases upregulation of genes and expression proteins and growth factors critical to bone healing.

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COX-211
Vital to the production of PGE2, critical for bone repair

Cell Differentiation28
Convert stem cells to osteoblasts
VEGF28
Stimulates the growth of new blood vessels
BMP2,11 BMP4,11 BMP6,11 BMP727
Essential to the creation of new bone
Mineralization21
Increases bone mineral density

Bone healing at every stage1

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Inflammation
EXOGEN’s ultrasound signal increases cell division among the periosteal cells in culture and upregulates growth factors that trigger the formation of new blood vessels.28

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Soft Callus
The ultrasonic treatment enhances the TGFB-triggered differentiation of chondrocytes in culture and accelerates the formation of extracellular matrix.29,30

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Hard Callus
EXOGEN upregulates endochondral ossifications8,9 and enhances osteoblast differentiation26 and mineralization.28

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Bone Remodeling
Accelerating both the formation and resorption of bone, EXOGEN ultrasound treatment yields faster remodeling of the mineralized callus.31

  • High treatment
    compliance21
  • +
  • Proven clinical
    effectiveness2-4
  • > >
  • Successful fracture
    healing outcomes