How it works

Get EXOGEN Now

The Science of Bone Healing with EXOGEN

You can’t hear it working, but EXOGEN’s effects on bone healing have been evaluated in multiple clinical studies.*1-3,5,13-31

EXOGEN Mechanism of Action

Watch Now

The EXOGEN Bone Healing System uses safe, painless, low-intensity pulsed ultrasound (LIPUS) to amplify natural bone healing three ways:

null
Stimulation32EXOGEN sends ultrasound waves through the skin, creating movement that stimulates your body’s cells.
null
Activation33EXOGEN ultrasound activates cells in your body.
null
Upregulation34Upregulation is increased by EXOGEN ultrasound waves that increase factors that help jump start your body to heal your fracture.

EXOGEN Enhances Bone Healing at Every Stage†35

Within minutes of a bone fracture, the body begins a process to repair the damage. Healing a fracture involves several distinct stages. EXOGEN jumpstarts bone healing by stimulating your body’s natural healing process.

null

1. Inflammation

When a bone breaks, white blood cells move in to clean up debris created by the break. This creates inflammation, which triggers the growth of new blood cells—the first stage of healing.
null

3. Hard Callus

The body gradually replaces the soft callus with a hard callus, connecting the bone fragments more solidly. The stronger callus, which creates a bulge at the site of the fracture, can generally be seen in X-rays just a few weeks after the facture occurs.
null

2. Soft Callus

Blood cells divide and multiply near the break, and new blood vessels develop to fuel the repair process. The body also begins to create fibrous tissue to bridge the break in the bone. This material is called soft callus.
null

4. Bone Remodeling

In the final stage of bone fracture healing, the body replaces old bone with new in a process called remodeling. Remodeling makes bones stronger and more compact, and blood circulation in the bone improves.
Learn if EXOGEN is right for you

†In vivo data is not representative of clinical results

Summary of Indications for Use
EXOGEN is indicated for the non-invasive treatment of osseous defects (excluding vertebra and skull) that includes the treatment of delayed unions, nonunions,* stress fractures and joint fusion. EXOGEN is also indicated for the acceleration of fresh fracture heal time, repair following osteotomy, repair in bone transport procedures and repair in distraction osteogenesis procedures.

There are no known contraindications for the EXOGEN device. Safety and effectiveness have not been established for individuals lacking skeletal maturity, pregnant or nursing women, patients with cardiac pacemakers, on fractures due to bone cancer, or on patients with poor blood circulation or clotting problems. Some patients may be sensitive to the ultrasound gel.

Full prescribing information can be found in product labeling, at EXOGEN.com, or by calling Bioventus Customer Service.

*A nonunion is considered to be established when the fracture site shows no visibly progressive signs of healing.